Pharmacological Management of Low Blood Flow State in Less than 28 weeks Neonates

Arrowe Park Hospital, Wirral University Teaching Hospital, Arrowe Park Road, Birkenhead, Wirral, CH49 5PE, UK

*Corresponding Author: Femi Adeniyi, Arrowe Park Hospital, Wirral University Teaching Hospital, Arrowe Park Road, Birkenhead, Wirral, CH49 5PE, UK, E-mail: [email protected].

Received: January 18, 2021

Published: June 29, 2021

Citation: Adeniyi F, et al. (2021). Pharmacological Management of Low Blood Flow State in Less than 28 weeks Neonates. Neonatal. 2(1):04.

Copyright: Adeniyi F, et al. ©2021.

BRIEF OVERVIEW

Low blood flow state is defined as insufficient cardiac output to maintain adequate cellular metabolism at the organ level. Low blood flow state can be measured by reduced organ perfusion such as reduced superior vena cava flow [1,2] or high resistance flow in superior mesenteric doppler [3]. According to Melitin J, et al. (2008) [4], capillary refill time of greater than 4 seconds and serum lactate greater than 4mmol/litre has 97% sensitivity of identifying low blood flow state.

In the presence of above markers of low blood flow state, the blood pressure may be normal or high in the first 48 hours of life due to high systemic resistance [5]. Therefore, high or normal blood pressure should be interpreted with great caution.

Literatures was sourced through health care database advanced search using articles and journals from Medline, PubMed and Embase in designing evidenced based guidance on pharmacological treatment of low blood flow state (Appendix 1).

KEYWORDS: Preterm; Prematurity; Extreme Prematurity AND Hypotension; Low blood pressure AND Inotropes; Therapeutics; Pharmacological